This research will perform scenario-based analysis to measure the epidemiological and economic impact of COVID- 19 in the US. We will use several counterfactual scenarios, guided by the CDC and current interventions to build an experimental design. These will include high vs. low severity, different levels of transmissibility, different social distancing strategies (school closure, home isolation, quarantine of contacts of symptomatic cases), compliance levels, lockdown duration etc. This research will also analyze different vaccine allocation strategies that address issues of efficacy, efficiency, hesitancy and fairness. The ultimate goal is to provide guidance to public health officials for developing strategies to balance the emergence of infections and deaths with the economic costs of the lockdown.