We partnered with Fairfax County and Inova Translational Medicine Institute to better understand regional health and well-being through a data science framework. Our research team used an interdisciplinary, data-driven approach to discover, acquire, and statistically integrate publicly available local data and create CommunityScapes – social, economic, environmental, and well-being indicators at sub-county levels. We developed obesogenic environment exposure and economic vulnerability composite indices, mapping social determinants of health that influence neighborhood well-being.