Network Systems Science and Advanced Computing

Projects

All Projects

In 2004, NIH/NIAID initiated the Bioinformatics Resource Centers for Infectious Diseases program. It provides public access to computational platforms and analysis tools that enable the collecting and integration of genomics and related research data relevant to infectious diseases, pathogens, and their interaction with host organisms. The Bacterial and Viral Bioinformatics Resource Center (BV-BRC) is utilized in this program.
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Population Health Informatics,Systems Biology and Bioinformatics
Behavioral and Environmental Sensing and Intervention for Cancer (BESI-C) is a Smart Health sensing system created by engineers and clinicians at the University of Virginia designed to monitor, predict and manage cancer pain in the home setting. Managing cancer pain at home can be stressful and challenging, but BESI-C offers a user-friendly and non-invasive solution.
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Social, Cognitive, and Behavioral Science
Past Project
We are studying the spread of invasive plants in the Chitwan Annapurna Landscape (CHAL) of Nepal, which is part of a biodiversity hotspot. This problem of invasive species is an impediment to the achievement of multiple sustainable development goals drafted by the United Nations. CHAL has a rich diversity of flora and fauna, which is unfortunately threatened by the combined effects of climate change and increased human activities.
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Resilient Societies and Interdependent Infrastructures
The Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) project aims to reduce malaria transmission by administering ivermectin to humans and livestock. Ivermectin is an endectocide drug with an excellent safety profile that can kill ecto- and endoparasites, as well as mosquitoes that feed on treated humans or animals.
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Population Health Informatics
The major goal of this project is to design, build, verify, and deploy an open-access general-purpose CI for network science, which we call net.science.
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Resilient Societies and Interdependent Infrastructures
The SIF-funded program proposes planning and response strategies to contagious phenomena (e.g. infectious disease outbreaks, network contagion, et al) as a complex system big science problem.
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Resilient Societies and Interdependent Infrastructures
The overall goal of this project is to develop methods for prediction of incidence rates and patient risk to HAIs and evaluate interventions to control their spread. The mechanisms of HAI transmission and antimicrobial resistance are very complex, and the available data are sparse and noisy. Therefore, risk prediction and evaluation of interventions cannot be done by simple statistical models restricted to one hospital.
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Population Health Informatics
The National Resource for Mechanistic Modeling of Cellular Systems will offer deep insights into mechanisms by which cells function and the cellular basis of disease through its computational modeling, enabled by the Complex Pathway Simulator (COPASI) and Virtual Cell (VCell) technologies. Projects by our user base focused on cancer, neurological disorders, diabetes, kidney disease, cardiology, and aging, all utilize mathematical models developed through VCell and COPASI.
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Systems Biology and Bioinformatics
We aim to conduct transformative research on physical and social aspects of coastal vulnerability embedded in interdependent infrastructures by developing a highly integrated modeling framework. We establish the notion of decentralized resilience as a cascade-proofing mechanism in Critical Interdependent-infrastructure Systems and Processes (CRISP) to expand the landscape of thinking and planning resilience.
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Social, Cognitive, and Behavioral Science
Hospital Acquired Infections (HAIs) are becoming a major challenge in today’s health systems worldwide; many of these infections are becoming resistant to antibiotics, which makes their treatment very difficult.
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Population Health Informatics